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Candesartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues
ClH/c1-16(15-21-18-10-6-3-7-11-18)20(13-12-19)14-17-8-4-2-5-9-17
Meagher EA
LY294002 was used at 10-50 µM final concentration in various in vitro assays
Smiles: OCCOCCN1CCN(CC1)C1=NC2=CC=CC=C2S(=O)C2=CC=CC=C12
S1RA Size:Solid 10 mg Candesartan blocks the vasoconstrictor andE 52862, also known as S1RA and MR390, is a selective sigma 1 receptor antagonist, with a reported binding affinity of Ki = 17. 0 7. 0 nM, selective over the sigma 2 receptor and against a panel of other 170 receptors, enzymes, transporters and ion channels. In preclinical studies, S1RA has demonstrated efficacy in relieving neuropathic pain and pain in other sensitizing conditions, associated with an improvement of the emotional negative state. E
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